We have came across the following error quite a few times.
Your PHP installation appears to be missing the MySQL extension which is required by WordPress
Though it may sound tricky, the error can be quickly fixed by installing missing PHP libraries. This often happens because of the upgrades.
In PHP 7.x we can fix using the following
sudo apt-get install php-mysql
Older PHP versions can be fixed by the following
sudo apt-get install php5-mysqlnd-ms
Don’t forget to restart Apache / Nginx or the relevant web server to load the libraries / modules.